Association of cyclooxygenase-2 genetic variant with cardiovascular disease

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Association of cyclooxygenase-2 genetic variant with cardiovascular disease.

AIM A genetic variant (rs20417) of the PTGS2 gene, encoding for COX-2, has been associated with decreased COX-2 activity and a decreased risk of cardiovascular disease (CVD). However, this genetic association and the role of COX-2 in CVD remain controversial. METHODS AND RESULTS The association of rs20417 with CVD was prospectively explored in 49 232 subjects (ACTIVE-A, CURE, epiDREAM/DREAM, ...

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Genetic association of cyclooxygenase-2 gene polymorphisms with Parkinson's disease susceptibility in Chinese Han population.

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Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma

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Cyclooxygenase-2 in Cardiovascular Biology

Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identifi ed, COX-1 and COX-2. Generally, the COX-1 enzyme is produced constitutively (e.g. in gastric mucosa), whereas COX-2 is highly inducible (e.g. at sites of infl ammation and cancer). Traditional non-steroi...

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ژورنال

عنوان ژورنال: European Heart Journal

سال: 2014

ISSN: 1522-9645,0195-668X

DOI: 10.1093/eurheartj/ehu168